High-Dose Vitamin C IV

Overview

Why Clients Choose It

High-dose intravenous vitamin C bypasses gut absorption limits to deliver therapeutic antioxidant and immune support. Prescribed after a brief medical screen (including G6PD clearance).

Powerful antioxidant and immune support
Supports collagen synthesis and tissue repair
Reduces oxidative stress and inflammation
Adjunct in integrative wellness protocols

Requires G6PD lab clearance prior to first dose. Administered over ~60 minutes. Series and cadence customized during consultation.

The Mechanism

How High-Dose Vitamin C IV Works

Oral vitamin C absorption is saturated by intestinal SVCT1 transporters at roughly 200 mg per dose, capping plasma levels near 80 μmol/L. Intravenous administration bypasses this ceiling, achieving plasma concentrations 30–70× higher — a range with distinct pharmacologic activity.
At millimolar plasma levels, ascorbate acts as a pro-oxidant in the extracellular space, generating hydrogen peroxide that selectively stresses damaged and pathogenic cells while leaving healthy cells (which contain catalase) untouched.
Vitamin C is also a required cofactor for collagen hydroxylation, carnitine synthesis, and the recycling of vitamin E and glutathione — placing it at the center of tissue repair and antioxidant defense.

Inside the Bag

What Is In The Formulation

Ascorbic acid (Vitamin C) — Antioxidant, immune support, collagen cofactor — 10–25 g titrated
Sterile saline vehicle — Osmotic buffering for high-dose delivery
Optional add-ons — Zinc, B-complex or glutathione for targeted goals

Evidence

What The Research Shows

Padayatty et al., Annals of Internal Medicine (2004) established the pharmacokinetic gap between oral and IV vitamin C.

Carr & Maggini, Nutrients (2017) reviewed vitamin C's roles across innate and adaptive immunity — from neutrophil chemotaxis to lymphocyte proliferation.

Ongoing integrative-oncology and sepsis literature (e.g., Fowler et al., JAMA 2019) continues to characterize high-dose IV vitamin C's inflammatory and adjunctive effects.

Best Suited To

Who This Drip Is For

Immune resilience through the seasons
Post-illness or post-surgical recovery
Chronic inflammation support

Your Visit

Before Your First Drip

Weekly during active recovery or immune stress; every 2–4 weeks for maintenance. Series length is set with your clinician.

G6PD lab clearance required before first infusion (hemolysis risk in G6PD-deficient patients)
Renal function screen for higher doses
Not appropriate with iron-overload disorders or oxalate nephropathy history
Coordination with oncology team required if in active treatment

Questions

Frequently Asked Questions

Why do I need a G6PD test?

Glucose-6-phosphate dehydrogenase deficiency is an inherited condition (~5% prevalence globally) that can cause red blood cell breakdown with high-dose vitamin C. A single lab draw rules this out for life.

Can I get more vitamin C from food or oral supplements?

Oral vitamin C tops out at plasma levels around 80 μmol/L due to gut absorption limits. IV delivery reaches concentrations that food and pills physically cannot achieve.

How often should I come in?

Weekly during acute recovery, every 2–4 weeks for maintenance. Your clinician tailors cadence to your goals and follow-up labs.

The Drip Menu

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